Ligandconjugated liposomes are designed to target receptors which are overexpressed on tumor cells to decrease drugs side effects by. To overcome these limitations ligand targeted liposomes were developed. Moreover, the penetration of anticancer drugs into tumor tissues is. Masking and triggered unmasking of targeting ligands on. The discovery of phospholipids spontaneously forming spherical, selfclosed bubbles known as liposomes, upon dispersion in water, ushered a new era in drug delivery technology. In this context, encapsulation of anticancer drugs within the liposomal system. Updates on the use of liposomes for active tumor targeting in cancer. Selective targeting of ligandtargeted liposomes containing anticancer drugs or therapeutic genes to cell surface receptors expressed on cancer cells is a recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics or gene therapeutics.
Ligand targeted liposomes ltl s the conventional liposomal systems have some limitations such as res uptake, opsonization, and immunogenicity. Qianyu zhang, jie tang, rui ran, yayuan liu, zhirong zhang, huile gao, qin he. Ligandtargeted liposomes for cancer treatment bentham. Liposomal drug delivery systems and anticancer drugs mdpi. Antibody or ligandmediated targeting of liposomal anticancer drugs to antigens expressed selectively or overexpressed on tumor cells is increasingly being recognized as an effective strategy for increasing the therapeutic indices of anticancer drugs. Liposomal drug delivery systems for targeted cancer therapy. Continuous and systematic research over the last few decades has resulted in the development of tailormade liposomal formulations authors contributed equally. James mixson 1 1 department of pathology, university of maryland school of medicine, 10 s.
While ligand targeted liposomes have been reported to improve drug. Pdf ligand mediated drug targeted liposomes researchgate. Pdf liposomal drug delivery systems and anticancer drugs. Liposomes as carriers of anticancer drugs intechopen. The design of peptideamphiphiles as functional ligands for liposomal anticancer drug and gene delivery. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Development of ligandtargeted liposomes for cancer. Pdf ligandtargeted liposomal therapies of neuroblastoma. Ligand, target, some types of cancer that overexpress the target cell. Selected list of ligand targeted nanoparticulate systems evaluated for in vitro or in vivo therapeutics delivery. They enhance the therapeutic index of anticancer drugs by increasing the drug concentration in tumor cells through tumor targeting. Ligandtargeted liposomal anticancer drugs sciencedirect. Some recent advances in the field of ligandtargeted liposomes for the treatment of cancer are summarized including. Liposomal nanoparticles loaded with doxorubicin, and targeted against the.
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